More than two months after Nancy Guthrie’s disappearance, officials have no suspects, but a DNA expert suggests a breakthrough could be imminent. CeCe Moore, chief genetic genealogist at Parabon Nanolabs, believes authorities should return to Guthrie’s Arizona home to collect additional DNA samples. Prior samples were “mixed,” containing genetic material from multiple people, a common issue in forensic investigations.
Moore explained that advances in DNA technology—particularly whole genome sequencing—are making it easier to detect tiny amounts of DNA, increasing the likelihood of mixed samples. However, current techniques struggle to deconvolute these complex mixtures. She noted that companies working with law enforcement are accelerating the release of new software to address this challenge, partly due to the high-profile nature of Guthrie’s case.
Pima County Sheriff Chris Nanos confirmed that the lab processing the DNA samples reported difficulties, and it could take months before the evidence is ready for investigative genetic genealogy (IGG). Moore remains optimistic, stating that Guthrie’s case has made this a priority, and she is confident that the kidnapper left DNA in the home.
Guthrie, 84, was last seen at her home on January 31 and reported missing on February 1. Authorities believe she was kidnapped after finding drops of her blood on the front porch. The FBI released surveillance footage from a doorbell camera in February, but no suspects have been identified.